VASG Alfaxalone | 動物用藥查詢網
![VASG Alfaxalone](https://i.imgur.com/TbfVXFL.jpg)
Inductiondose.i.v.;Dogs.1–3mg/kg(0.5–1.5mg/lb);Cats.2–5mg/kg(1.0–2.5mg/lb) ...
![VASG Alfaxalone](https://i.imgur.com/TbfVXFL.jpg)
Alfaxalone is not a new drug. It was originally introduced in the 1970s as a mixture with alfadolone. The brand names were Althesin® for the human product and Saffan® for the veterinary market. Both products were withdrawn from the market because of severe adverse effects. These adverse effects (histamine release and anaphylactic reactions) were very probably caused by the solubilising agent Cremophor EL®, a derivate of castor oil.
Alfaxalone is remarketed as a water-soluble neuroanaesthetic. Water solubility was achieved by binding the alfaxalone-molecule to a cyclodextrine molecule. It is rapidly metabolized by the liver and does not cause histamine release like the former formulation. Alfaxalone’s anaesthetic action is due to its binding to GABA-receptors.
With the introduction of Alfaxan® veterinarians have access to another anesthetic with a ...
Alfaxalone | 動物用藥查詢網
Alfaxan (alfaxalone 10 mgmL) | 動物用藥查詢網
Alfaxan Multidose Administration Guide for Dogs and Cats | 動物用藥查詢網
Intravenous Induction Dose Guide | 動物用藥查詢網
Sedative effects of intramuscular alfaxalone administered to cats | 動物用藥查詢網
VASG Alfaxalone | 動物用藥查詢網
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