Activity of colistin combined with doripenem at clinically ... | 動物用藥查詢網
![Activity of colistin combined with doripenem at clinically ...](https://i.imgur.com/TbfVXFL.jpg)
由JLora-Tamayo著作·2014·被引用64次—Doripenemenhancedkillingbycolistinofbiofilm-embeddedcellsinboth...concentrationsagainstmultidrug-resistantPseudomonasaeruginosainanin ...
![Activity of colistin combined with doripenem at clinically ...](https://i.imgur.com/TbfVXFL.jpg)
Objectives: Colistin combination therapy may be required to treat biofilm-associated infections. We evaluated bacterial killing and emergence of colistin resistance with colistin and doripenem combinations against biofilm-embedded and planktonic multidrug-resistant (MDR) Pseudomonas aeruginosa.
Methods: One colistin-susceptible reference strain (PAO1) and two colistin-susceptible MDR clinical isolates (HUB1 and HUB2; both carbapenem resistant) were investigated over 72 h in the CDC biofilm reactor, a dynamic biofilm model. Two colistin regimens (constant concentrations of 1.25 and 3.50 mg/L), one doripenem regimen (Cmax 25 mg/L 8 hourly) and their combination were employed. Microbiological response was examined as log changes and absolute bacterial counts.
Results: For biofilm-embedded bacteria, bactericidal activity was only observed with monotherapy with colistin at 3.50 mg/L. The...
Activity of colistin combined with doripenem at clinically ... | 動物用藥查詢網
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