Trastuzumab Deruxtecan in Previously Treated ... | 動物用藥查詢網
由SModi著作·2022·被引用323次—InthistrialinvolvingpatientswithHER2-lowmetastaticbreastcancer,trastuzumabderuxtecan...DESTINY-Breast04TrialInvestigators:.
Background: Among breast cancers without human epidermal growth factor receptor 2 (HER2) amplification, overexpression, or both, a large proportion express low levels of HER2 that may be targetable. Currently available HER2-directed therapies have been ineffective in patients with these "HER2-low" cancers.
Methods: We conducted a phase 3 trial involving patients with HER2-low metastatic breast cancer who had received one or two previous lines of chemotherapy. (Low expression of HER2 was defined as a score of 1+ on immunohistochemical [IHC] analysis or as an IHC score of 2+ and negative results on in situ hybridization.) Patients were randomly assigned in a 2:1 ratio to receive trastuzumab deruxtecan or the physicians choice of chemotherapy. The primary end point was progression-free survival in the hormone receptor-positive cohort. The key secondary end points were progression-free survival among al...
Trastuzumab Deruxtecan in Previously Treated HER2 | 動物用藥查詢網
Trastuzumab Deruxtecan in Previously Treated HER2 | 動物用藥查詢網
Trastuzumab Deruxtecan versus Trastuzumab Emtansine for ... | 動物用藥查詢網
DESTINY Clinical Trials for Metastatic Breast Cancer | 動物用藥查詢網
updated results from DESTINY-Breast03 | 動物用藥查詢網
DESTINY | 動物用藥查詢網
Trastuzumab Deruxtecan in Previously Treated ... | 動物用藥查詢網
Trastuzumab Deruxtecan (DS | 動物用藥查詢網
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