一期药物代谢 | 動物用藥查詢網
![一期药物代谢](https://i.imgur.com/TbfVXFL.jpg)
图1.我们的肝微粒体细胞色素P450酶是膜结合氧酶,在活性位点附近含有硫醇盐血红素。用于氧化机制的电子供给是由偶联的NAD(P)H还原酶和细胞色素b5系统提供的。直到最近, ...
![一期药物代谢](https://i.imgur.com/TbfVXFL.jpg)
Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation. Additional metabolism occurs in gastrointestinal epithelial, renal, skin, and lung tissues. Within cells, most phase I enzymes are located in the endoplasmic reticulum and thus are enriched in microsomal preparations.
Phase I reactions are broadly grouped into three categories: oxidation, reduction, and hydrolysis. As most small molecule drugs are lipophilic in nature, drug metabolism converts these hydrophobic compounds into more water soluble compounds that can be excreted. Typically, oxidation is the most common phase I reaction. The hepatic cytochrome P450 system is the most important of the phase I oxidation systems (...
一期药物代谢 | 動物用藥查詢網
一期药物代谢 | 動物用藥查詢網
肝臟之藥物轉化機制(Drug Metabolism) | 動物用藥查詢網
藥物誘發的肝毒性(Drug induced hepatotoxicity) | 動物用藥查詢網
認識藥物性肝損害 | 動物用藥查詢網
趙藥師藥局 | 動物用藥查詢網
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